Journal
ANALYST
Volume 139, Issue 17, Pages 4181-4184Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4an00561a
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Funding
- National Natural Science Foundation of China [21175039, 21190044, 21221003, 21322509, 21305035, 21305038]
- Hunan Province Science and Technology Project of China [2013FJ4042]
- Fundamental Research Funds for the Central Universities
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A novel label-free tailed hairpin-shaped activatable aptamer probe (THAAP) was developed by rationally integrating an aptamer and a split G-quadruplex into one sequence. Based on target recognition-triggered in situ catalysis of split DNAzyme, the THAAP strategy achieved a simple, fast, washing-free, specific and quantitative colorimetric assay of human leukemic CCRF-CEM cells.
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