Journal
ATHEROSCLEROSIS
Volume 194, Issue 1, Pages 204-213Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2006.07.028
Keywords
myocardial infarction; adiponectin; prognosis; sex
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There is conflicting information about whether mortality after AMI is higher in women than men. We investigated the significance of plasma adiponectin concentrations on major adverse cardiac events (MACE) after acute myocardial infarction (AMI) to delineate any differences between men and women. The study patients consisted of 114 men and 42 women with AMI. The incidence of MACE was significantly higher in women than men during the entire follow-up period (p<0.05). Compared with men for post-AMI MACE, the hazard ratio for women was 5.6 after adjustment for prognostic factors. Killip class (p < 0.00 1) and sex differences (p < 0.05) were independent predictors of MACE at I year post-AMI. Plasma adiponectin levels in women were significantly higher than men on admission (8.66 mu g/mL [range: 6.6-14.081 versus 4.71 mu g/mL [range: 3.47-7.271, p < 0.000 1) and during the post-AMI course (all p < 0.000 1). Multivariate analysis identified plasma adiponectin level on admission as an independent predictor of MACE in men (p < 0.00 1) and the difference between plasma adiponectin levels at discharge and on admission in women (p < 0.05). Patterns of serial changes in plasma adiponectin concentrations are different between men and women and plasma adiponectin concentrations can be used to predict future adverse cardiac events in AMI patients. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
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