Journal
ANALYST
Volume 138, Issue 11, Pages 3097-3103Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an00119a
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Funding
- National Natural Science Foundation of China [21175008, 21027012]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
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The development of rapid screening and identification techniques is of great importance for drug discovery, doping control, forensic identification, food safety and quality control. Ambient mass spectrometry (AMS) allows rapid and direct analysis of various samples in open air with little sample preparation. Recently, its applications in high-throughput screening have been in rapid progress. During the past decade, various ambient ionization techniques have been developed and applied in high-throughput screening. This review discusses typical applications of AMS, including DESI (desorption electrospray ionization), DART (direct analysis in real time), EESI (extractive electrospray ionization), etc., in high-throughput screening (HTS).
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