Journal
ANALYST
Volume 138, Issue 7, Pages 1988-1994Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an36791f
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Funding
- Hong Kong Polytechnic University Central Research Grant [G-U884]
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A novel and highly sensitive fiber-optic DNA sensor based on a thin-core fiber modal interferometer (TCFMI) is demonstrated by using a layer-by-layer (LbL) self-assembly technology. Poly(ethylenimine) (PEI), poly(acrylic acid) (PAA) and single-stranded DNA (ssDNA) were used for the preparation of a polyelectrolyte multilayer film for DNA detection. The film thickness was measured through a surface profilometer. The surface morphologies of (PEI/PAA)(4), (PEI/PAA)(4.5) and (PEI/PAA)(4)(PEI/DNA)(1) multilayer films were characterized by atomic force microscopy. The fabricated DNA sensors were tested with different types of target ssDNA solutions with a concentration of 1 mu M. The results show that the sensitivity of the TCFMI-based ssDNA sensor is 0.27 nm/matched-base at the concentration of 1 mM and can even distinguish the number of matched bases of ssDNA chains.
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