Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 9, Pages 1387-1396Publisher
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.070516
Keywords
osteoblast; osteoclast; urokinase receptor; bone remodeling; osteoporosis
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The uPAR and its ligand uPA are expressed by both osteoblasts and osteoclasts. Their function in bone remodeling is unknown. We report that uPAR-lacking mice display increased BMD, increased osteogenic potential of osteoblasts, decreased osteoclasts formation, and altered cytoskeletal reorganization in mature osteoclasts.
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