Journal
MOLECULAR ONCOLOGY
Volume 1, Issue 2, Pages 196-204Publisher
WILEY
DOI: 10.1016/j.molonc.2007.05.007
Keywords
Chemoprevention; Green tea catechins; Prostate cancer; Transgenic adenocarcinoma mouse; prostate model; Minichromosome maintenance; protein 7
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Funding
- National Cancer Institute [CA098522, CA085052]
- ABO Project 2010
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Green tea catechins (GTCs) exert chemopreventive effects in many cancer models. Several studies implicate the DNA synthesis marker minichromosome maintenance protein 7 (MCM7) in prostate cancer progression, growth and invasion; representing a novel therapeutic target. In this study, we investigated the effect of GTCs on MCM7 expression in the transgenic adenocarcinoma mouse prostate model (TRAMP). DNA microarray, immunohistochemistry and Western blot analysis showed that GTCs significantly suppressed MCM7 in the TRAMP mice treated with GTCs. Our study indicates that the cellular DNA replication factor MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by GTCs. Together, these results suggest a possible role of GTCs in CaP chemoprevention in which MCM7 plays a critical role. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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