Analysis of Effectiveness of Intracellular Penetration of Ivermectin Immobilized onto Corpuscular Carriers

Penetration of ivermectin adsorbed on the surface of colloidal gold particles or included in micelles to phagocytic cells of the immune system was studied. Detection of the preparation in the cells was carried out by the immunochemical method, employing miniantibodies to ivermectin obtained from a combinatory phage library and by the chromatographic method using the HPLC system Stayer. It was found that accumulation of ivermectin adsorbed on colloidal gold particles was accumulated in the cells most intensively than in the case of other carriers.