Journal
CANCER RESEARCH
Volume 67, Issue 17, Pages 8131-8138Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-06-4493
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Funding
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [K01 CA120099-01] Funding Source: Medline
- NIDDK NIH HHS [R01 DK067356] Funding Source: Medline
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The identification of mammary gland stem cells (MGSC) or progenitors is important for the study of normal breast development and tumorigenesis. Based on their immunophenotype, we have isolated a population of mouse mammary gland cells that are capable of forming mammospheres in vitro. Importantly, mammospheres are enriched for cells that regenerate an entire mammary gland on implantation into a mammary fat pad. We also undertook cytogenetic analyses of mammosphere-forming cells after prolonged culture, which provided preliminary insight into the genomic stability of these cells. Our identification of new cell surface markers for enriching mammosphere-initiating cells, including endoglin and prion protein, will facilitate the elucidation of the cell biology of MGSC.
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