4.6 Article

A highly specific BODIPY-based probe localized in mitochondria for HClO imaging

Journal

ANALYST
Volume 138, Issue 20, Pages 6091-6096

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an01152f

Keywords

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Funding

  1. NSF of China [21136002, 20923006, 21076032]
  2. National Basic Research Program of China [2009CB724706, 2013CB733702]
  3. National High Technology Research and Development Program of China (863 Program) [2011AA02A105]
  4. Ministry of Education [NCET-12-0080]

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An oxime containing fluorescent probe based on a BODIPY scaffold was successfully designed and used for HClO determination with rapid response, low detection limits and high selectivity. Confocal fluorescence microscopy demonstrated that the probe could permeate the mitochondria and made possible the fast fluorescent imaging of endogenous HClO.

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