Journal
JOURNAL OF DENTAL RESEARCH
Volume 86, Issue 9, Pages 862-867Publisher
INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R
DOI: 10.1177/154405910708600911
Keywords
bone; healing; implants; osteoblast
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Funding
- NIA NIH HHS [R01 AG23218-01] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000504] Funding Source: Medline
- NIDCR NIH HHS [R03 DE16701, R01 DE024000] Funding Source: Medline
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While bone healing occurs around implants, the extent to which this differs from healing at sites without implants remains unknown. We tested the hypothesis that an implant surface may affect the early stages of healing. In a new mouse model, we made cellular and molecular evaluations of healing at bone-implant interfaces vs. empty cortical defects. We assessed healing around Ti-6Al-4V, poly( L- lactide- co- D, L,- lactide), and 303 stainless steel implants with surface characteristics comparable with those of commercial implants. Our qualitative cellular and molecular evaluations showed that osteoblast differentiation and new bone deposition began sooner around the implants, suggesting that the implant surface and microenvironment around implants favored osteogenesis. The general stages of healing in this mouse model resembled those in larger animal models, and supported the use of this new model as a test bed for studying cellular and molecular responses to biomaterial and biomechanical conditions.
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