Journal
ANALYST
Volume 138, Issue 1, Pages 62-71Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2an35254k
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Funding
- National Natural Science Foundation of China [90606003, 21190040]
- National Basic Research Program [2011CB911002]
- International Science and Technology Cooperation Program of China [2010DFB30300]
- Program for Changjiang Scholar and Innovative Research Team in University
- Program for New Century Excellent Talents in University [NCET-09-0338]
- Hunan Natural Science Foundation [10JJ7002]
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Living cell studies can offer tremendous opportunities for biological and disease studies. Due to their high sensitivity and selectivity, minimum interference with living biological systems, ease of design and synthesis, fluorescent nucleic acid probes (FNAPs) have been widely used in living cell studies, such as for intracellular detection, cell detection, and cell-to-cell communication. Here, we review the general requirements and the recent developments in FNAPs for living cell studies. We broadly classify these designs as hybridization probes and aptamer probes. For hybridization probes, we describe recently developed designs, such as nanomaterial-based and amplification-based hybridization probes. For aptamer probes, we discuss four general paradigms that have appeared most frequently in the literature: nanomaterial-based, nanomachine-based, cell surface-anchored and activatable aptamer probe designs in vivo. FNAPs promise to open up new and exciting opportunities in biological marks detection for a wide range of biological and medical applications.
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