Journal
ACTA BIOMATERIALIA
Volume 3, Issue 5, Pages 687-694Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2007.02.004
Keywords
tissue adhesive; porcine tissue; small intestinal submucosa; mussel adhesive protein; metal ion
Funding
- NICHD NIH HHS [R03 HD041371-01A1, R03 HD041371-02, R03 HD041371] Funding Source: Medline
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An adhesive protein extracted from marine mussels (Mytilus edulis) was used to bond strips of connective tissue for the purpose of evaluating the use of curing agents to improve adhesive curing. Specifically, mussel adhesive protein solution (MAPS, 0.5 mM dihydroxyphenylalanine) was applied, with or without the curing agents, to the ends of two overlapping strips of porcine small intestinal submucosa (SIS). The bond strength of this lap joint was determined after curing for 1h at room temperature (25 degrees C). The strength of joints formed using only MAPS or with only the ethyl, butyl or octyl cyanoacrylate adhesives were determined. Although joints bonded using ethyl cyanoacrylate were strongest, those using MAPS were stronger than those using butyl and octyl cyanoacrylates. The addition of 25 mM solutions of the transition metal ions V5+, Fe3+ and Cr6+, which are all oxidants, increased the bond strength of the MAPS joints. The V5+ gave the strongest bonds and the Fe3+ the second strongest. In subsequent tests with V5+ and Fe3+ solutions, the bond strength increased with V5+ concentration, but it did not increase with Fe3+ concentration. Addition of 250 mM V5+ gave a very strong bond. (c) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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