Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 59, Issue 1, Pages 100-104Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2007.04.016
Keywords
cell adhesion; gold nanoparticle; paclitaxel; quartz crystal microbalance
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Cell adhesion is a crucial issue for cytotoxicity or anticancer effectiveness for tumor cells. However, how both nanoparticles and drugs affect cell adhesion has not yet been defined. Herein, we report for the first time that gold nanoparticles and Paclitaxel can disrupt adhesion, as well as enhance apoptosis of HepG2 cell individually and synergistically, as observed by in situ measurement usiner quartz crystal microbalance (QCM). It was also found by MTT assay that cold nanoparticles of low cellular cytotoxicity enhance the antiproliferation and apoptosis of HepG2 cell induced by Paclitaxel. Those findings would be of great potential for biomedical application of nanoparticles. (C) 2007 Elsevier B.V. All rights reserved.
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