Journal
ANALYST
Volume 138, Issue 4, Pages 981-990Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2an36500f
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Funding
- National Science Foundation of China [21075019, 41176079]
- '973' National Basic Research Program of China [2010CB732403]
- Research Fund for the Doctoral Program of Higher Education of China [20103514120003]
- National Science Foundation of Fujian Province [2011J06003]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1116]
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Recent research has looked to develop innovative, powerful and novel biofunctionalized nanoparticles, controlling and tailoring their properties in a very predictable manner to meet the needs of clinic immunoassays in the biomedical field. This minireview briefly summarizes recent advances covering the last 3 years, exploiting nanoparticle-based electrochemical, optical, mass-sensitive, colorimetric and immunodipstick assays. The enormous signal enhancement associated with the use of nanoparticles and formation of nanoparticle-antibody-antigen assemblies provide the basis for sensitive detection of disease-related proteins or biomarkers. Rather than being exhaustive, this minireview focuses on selected examples to illustrate novel concepts and promising applications. Finally, a small amount of speculation of possible future developments in nanoparticle-based immunoassays is provided.
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