Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 9, Pages 1338-1349Publisher
WILEY
DOI: 10.1359/JBMR.070605
Keywords
multipotential stromal cells from bone marrow; osteogenesis; microarray; mesenchymal stem cells; multipotential
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Funding
- NCRR NIH HHS [P40RR017447] Funding Source: Medline
- NIAMS NIH HHS [AR 47796, AR 48323] Funding Source: Medline
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In this study, we used multipotential MSCs and microarray assays to follow the changing patterns of gene expression as MSCs were differentiated to osteoblasts. We analyzed co-expressed gene groups to identify new targets for known transcription factor VDR during differentiation. The roles of two genes (histamine receptor HI and dermatopontin) as downstream targets for the VDR were confirmed by gel electromotility shift, siRNA inhibition, and chromatin immunoprecipitation assays.
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