Journal
ANALYST
Volume 137, Issue 19, Pages 4435-4439Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2an35900f
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Funding
- National Natural Science Foundation of China [211051111, 0905086, 10975179, 10905087, 61008056]
- Shanghai Municipal Natural Science Foundation [11ZR1445300]
- Main Direction Program of Knowledge Innovation of CAS [KJCX2-EW-N03]
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We have coupled gold nanoparticles with horseradish peroxidase (HRP) to assemble catalytic nanoconjugates (HRP-AuNPs) for glucose detection. We found that a proper mixing ratio of HRP/AuNPs can significantly improve catalytic activity for the cascade reaction, an effect arising from increased spatial coupling between enzymes. Such gold nanoparticle-based nanoconjugates are shown to be promising nanosensors for glucose.
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