Journal
CANCER GENETICS AND CYTOGENETICS
Volume 177, Issue 2, Pages 108-114Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cancergencyto.2007.07.002
Keywords
-
Categories
Funding
- NCI NIH HHS [R01 CA 100070, K12 CA090433, R01 CA100070-03, K12 CA90433, R01 CA100070, R21 CA114251-01, K12 CA090433-04, R21 CA114251] Funding Source: Medline
Ask authors/readers for more resources
Translocations involving the mixed-lineage leukemia gene (MLL) confer a poor prognosis in acute leukemias. In t(1;11)(q21;q23) MLL is fused reciprocally with AF1q. Here we describe a t(1: 11)(q21 q23) with a secondary event involving insertion of the telomeric portion of MLL into the p arm of chromosome 11 (11 p 11). We show that this latter event interrupts the CUG triplet repeat binding protein-1 (CUGBP1)gene, a translational enhancer of CIEBP ss. We then showed that these cells have reduced expression of CUGBP1 and C/EBP beta when compared to other AML blasts. This is the first report to describe insertional disruption of the CUGBP1 gene and to suggest a role for the CUGBP1-C/EBP beta pathway in leukemogenesis. (c) 2007 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available