Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 189, Issue 1-2, Pages 118-124Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2007.06.009
Keywords
HLA-DRB1*15; HLA-DRB1*1501; HLA-DRB1*1503; multiple sclerosis; Brazilians
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Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed population inserted in an environment of low MS prevalence. The present results suggest that a given HLA-DRB1 allele may exhibit different behaviors, i.e. confer resistance or susceptibility, in response to the environmental and/or genetic (ethnic) backgrounds that characterize a sampled population. (C) 2007 Elsevier B.V. All rights reserved.
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