Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 62, Issue 9, Pages 983-988Publisher
GERONTOLOGICAL SOC AMER
DOI: 10.1093/gerona/62.9.983
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Funding
- NHLBI NIH HHS [N01-HC-85079-85085, N01 HC045133, N01 HC075150, N01 HC085082, N01 HC085085, N01 HC085083, N01 HC085080, N01 HC085084, N01HC85079, N01 HC085079, HL 87079-87086, N01 HC085081] Funding Source: Medline
- NIA NIH HHS [TG32 AG00181, K23 AG026766-03, 1 P30 AG024827-01, K23 AG026766-02, 1 K23 AG026766-01, P30 AG024827, K23 AG026766, TG32AG00181, T32 AG000181, K23 AG026766-01, K23 AG026766-04] Funding Source: Medline
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Background. Gait speed is a strong predictor of incident walking disability. The objective was to determine if gait variability adds to the prediction of incident mobility disability independent of gait speed. Methods. Participants included 379 older adults (mean age = 79 years; 78% Caucasian, and 40% men) in the Cardiovascular Health Study at the Pittsburgh site. All could ambulate independently and reported no difficulty walking a half mile. Gait characteristics were determined from a 4-meter computerized walkway. For each gait parameter, variability was defined as the standard deviation from the individual steps from two passes. Incident walking disability was obtained by phone interview every 6 months for 54 months and was defined as new difficulty walking a half mile or inability to walk a half mile. Results. Of the 379 participants, 222 (58.6%) developed incident mobility disability. In unadjusted Cox proportional hazards models gait speed, mean step length, mean stance time, and stance time variability were associated with incident mobility disability. After adjusting for gait speed, demographics, chronic conditions, prescription medications, health status, and physical activity level, only stance time variability remained an important indicator of disability. In the adjusted model, an increase in stance time variability of 0.01 seconds was associated with a 13% higher incidence of mobility disability (hazard ratio 1.13, 95% confidence interval, 1.01-1.27). Conclusions. Stance time variability is an independent predictor of future mobility disability. Future efforts are needed to determine whether interventions that decrease stance time variability will also delay mobility disability.
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