Journal
ANALYTICAL CHEMISTRY
Volume 79, Issue 17, Pages 6697-6701Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac071062b
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Funding
- NIGMS NIH HHS [2 R01 GM059622-04] Funding Source: Medline
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Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.
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