Journal
ANALYST
Volume 137, Issue 14, Pages 3227-3229Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2an35138b
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Funding
- Department of State Fulbright Fellowship
- Department of Education Foreign Language and Area Studies Fellowship (FLAS)
- NIH [2RO1EB004761-06, R21EB010191-01A1]
- Rosalinde and Arthur Gilbert Foundation
- LSU-Board of Regents
- AFAR
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Here we report a novel method for the manipulation and concentration of A beta amyloid fibrils, implicated in Alzheimer's disease, using DC insulating gradient dielectrophoresis (DC-iGDEP). Fibril enrichment was found to be similar to 400%. Simulations suggest that capture of the full range of amyloid protein aggregates is possible with optimized device design.
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