Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 51, Issue 9, Pages 3449-3451Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01586-06
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Growth-kill dynamics were characterized in vitro, and the parameter estimates were used to simulate bacterial growth and kill in vivo using both mouse and human pharmacokinetics. The parameter estimates obtained in vitro predicted a time above the MIC of between 35 and 38% for a static effect in mice after 24 h of treatment.
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