Journal
ANALYST
Volume 137, Issue 20, Pages 4658-4661Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2an36006c
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Funding
- Development of System and Technology for Advanced Measurement and Analysis Program (SENTAN) from Japan Science and Technology Agency (JST)
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To perform remote and direct sampling for mass spectrometry, solid probe assisted nanoelectrospray ionization (SPA-nanoESI) has been newly developed. After capturing the sample on the tip of the needle by sticking it to the biological tissue, the needle was inserted into the solvent-preloaded nanoESI capillary from the backside. NanoESI gave abundant ion signals for human kidney tissues and the liver of a living mouse. The method is easy to operate and versatile because any biological specimen could be sampled away from the mass spectrometer. Minimal invasiveness is another merit of this method.
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