4.6 Article

Highly sensitive DNA hybridization detection with single nanoparticle flash-lamp darkfield microscopy

Journal

ANALYST
Volume 137, Issue 13, Pages 2930-2932

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2an16171k

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Funding

  1. National Natural Science Foundation of China [20975036, 91027037]

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We developed a novel method for counting single gold nanoparticles in free solution with flash-lamp darkfield microscopy and demonstrated that it could be applied to highly sensitive DNA hybridization detection based on target DNA induced AuNP aggregation and counts reduction.

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