Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 9, Pages 1329-1337Publisher
WILEY
DOI: 10.1359/JBMR.070517
Keywords
PTH; IGF-I signaling; osteoprogenitor; proliferation; bone formation rate
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Funding
- NIAMS NIH HHS [R01 AR055924] Funding Source: Medline
- NIDDK NIH HHS [R01 DK054793, R01 DK54793] Funding Source: Medline
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We showed that the IGF-IR-null mutation in mature osteoblasts leads to less bone and decreased periosteal bone formation and impaired the stimulatory effects of PTH on osteoprogenitor cell proliferation and differentiation.
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