Journal
DIABETES-METABOLISM RESEARCH AND REVIEWS
Volume 23, Issue 6, Pages 490-496Publisher
WILEY
DOI: 10.1002/dmrr.716
Keywords
peripheral nerve; nerve regeneration; diabetes mellitus; diabetic neuropathy
Categories
Ask authors/readers for more resources
Background Failed regeneration compounds the deficits imposed by diabetes from peripheral neuropathy. In this work, we addressed how diabetes or local glucose toxicity might impact peripheral nerve trunk regeneration and reconstitution across major sciatic nerve transection injuries of rats. Methods Specific conduits, amendable to manipulation of infused glucose concentrations through a T connection, were perfused with 5 or 30 mmol/L glucose in nondiabetics or 5 mmol/L glucose in rats with experimental diabetes. Quantitative early and later regenerative outgrowth was measured. Results Local glucose exposure had no impact on early axon or Schwann cell outgrowth or partnering nor later myelinated axon regeneration. Despite only mildly attenuated early sprouting of axons with Schwarnn cells, diabetic bridges exhibited massive later failure of reconstitution by 3 weeks after injury. Conclusion Diabetes is associated with severe limitations in regenerative success, despite appropriate early axon outgrowth. Copyright (C) 2007 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available