Journal
ANALYST
Volume 136, Issue 1, Pages 196-200Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0an00452a
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Funding
- NSFC [20771037, 20871047]
- Shuguang Project [06SG33]
- SRFDP [20070251014]
- Fundamental Research Funds for the Central Universities
- Program for Professor of Special Appointment at Shanghai Institutions of Higher Learning
- [NCET-06-0417]
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For the widely used Au nanoparticles (AuNPs)-based colorimetric probe, AuNPs generally change from the dispersion to the aggregation state and corresponding colors turn from red to blue concomitantly. In previous studies, there are few probes based on the anti-aggregation of AuNPs though anti-aggregation of AuNPs is preferable to aggregation to achieve higher selectivity. In this manuscript, a fast and simple but sensitive and selective sensor suitable for on-site and real-time detection of glutathione (GSH) has been developed based on the anti-aggregation of AuNPs. The sensor has a LOD of 8 nM and excellent selectivity toward GSH by a factor of 200-fold or more relative to natural amino acids as well as homocysteine (Hcys) and glutathione disulfide (GSSG). The dynamic range of the sensor can be tuned simply by adjusting the amount of aggregation agent used.
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