Journal
DEVELOPMENTAL DYNAMICS
Volume 236, Issue 9, Pages 2627-2635Publisher
WILEY
DOI: 10.1002/dvdy.21259
Keywords
dystroglycan; basement membrane; muscle; mouse
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Funding
- Wellcome Trust [GR077544AIA] Funding Source: Medline
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Using immunohistochemistry, we have examined P-Dystroglycan protein distribution in the mouse embryo at embryonic stages E9.5 to E11.5. Our data show that Dystroglycan expression correlates with basement membranes in many tissues, such as the notochord, neural tube, promesonephros, and myotome. In the myotome, we describe the timing of Dystroglycan protein re-distribution at the surface of myogenic precursor cells as basement membrane assembles into a continuous sheet. We also report on non-basement-membrane-associated Dystroglycan expression in the floor plate and the myocardium. This distribution often corresponds to sites of expression previously reported in adults, suggesting that Dystroglycan is continuously produced during development.
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