Journal
NATURE METHODS
Volume 4, Issue 9, Pages 717-719Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH1078
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Funding
- NCRR NIH HHS [P41-RR02594-18] Funding Source: Medline
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We report a technique for quantitative three-dimensional (3D) mapping of refractive index in live cells and tissues using a phase-shifting laser interferometric microscope with variable illumination angle. We demonstrate tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure. Our results will permit quantitative characterization of specimen-induced aberrations in high-resolution microscopy and have multiple applications in tissue light scattering.
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