Journal
DNA REPAIR
Volume 6, Issue 9, Pages 1386-1390Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2007.03.018
Keywords
DNA damage; DNA repair; nucleotide excision repair; ERCC1; XPF; aging; progeroid change; cancer; IGF1
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Funding
- NCI NIH HHS [P01 CA077852, P01 CA077852-10] Funding Source: Medline
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Two recent reports provide new information on how DNA damage may generate progeroid changes at the cell and organismal level by suppressing growth hormone (GH)/insulin-like growth factor 1 (IGF1) endocrine signaling. This endocrine signaling pathway is of particular interest as it is a key regulator of metabolism and longevity in many organisms. (C) 2007 Elsevier B.V. All rights reserved.
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