Journal
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
Volume 31, Issue 6, Pages 436-446Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compmedimag.2007.04.002
Keywords
functional MRI; data analysis; imaging phantoms; ROC analysis; image processing
Funding
- NCRR NIH HHS [M01 RR000095-39, M01 RR000095, M01 RR00095] Funding Source: Medline
- NINDS NIH HHS [R01 NS046077-03, R01 NS046077] Funding Source: Medline
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The objectives of this study were to use computer-generated phantoms containing real subject motion to: (1) compare the sensitivity of four commonly used fMRI software packages and (2) compare the sensitivity of three statistical analysis strategies with respect to motion correction. The results suggest that all four packages perform similarly in fMRI statistical analysis with SPM2 having slightly higher sensitivity. The most sensitive analysis technique was to perform motion correction and include the realignment parameters as regressors in the general linear model. This approach applies to all four packages examined and can be most beneficial when stimulus-correlated motion is present. (c) 2007 Elsevier Ltd. All rights reserved.
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