Journal
ANALYST
Volume 135, Issue 11, Pages 2970-2978Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0an00265h
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Funding
- Medical Center Construction Foundation of Xiamen
- Fujian Province Department of Science Technology
- National Natural Science Foundation of China [20775063]
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Serum samples from kidney cancer patients and healthy controls were analyzed by both direct infusion mass spectrometry (DIMS) and liquid chromatography-mass spectrometry (LC-MS) with a high resolution ESI-Q-TOFMS. The classification and biomarker discovery capacities of the two methods were compared, and MS/MS experiments were carried out to identify potential biomarkers. DIMS had comparable classification and prediction capabilities to LC-MS but consumed only similar to 5% of the analysis time. With regard to biomarker discovery, twenty-three variables were found as potential biomarkers by DIMS, and 48 variables were obtained by LC-MS. DIMS is recommended to be a fast diagnostic method for kidney cancer, while LC-MS is necessary when comprehensive screening of biomarkers is required.
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