Journal
ANALYST
Volume 135, Issue 11, Pages 2798-2801Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0an00477d
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Funding
- Network of Computational Nanotechnology (NCN)
- National Institute of Health [NIH-R01CA120003]
- Materials Structures and Devices Center of the Semiconductor Research Center [MSD 104309]
- NATIONAL CANCER INSTITUTE [R01CA120003] Funding Source: NIH RePORTER
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A scaling theory of the sub atto-molar (aM) detection limits of magnetic particle (MP) based biosensors (e. g., bio-barcode assays) is developed and discussed. Despite the dramatic differences of sensing protocols and detection limits, the MP-based sensors can be interpreted within the same theoretical framework as any other classical biosensor (e. g., nanowire sensors), except that these sensors are differentiated by the geometry of diffusion and the probe (rho(MP))/target (rho(T)) density ratio. Our model predicts two regimes for biomolecule detection: For classical biosensors with rho(MP) <= rho(T), the response time t(s)proportional to 1/rho(T); while for MP-based biosensors with rho(MP) > rho(T), t(s)proportional to 1/rho(MP). The theory (i) explains the performance improvement of MP-sensors by rho(MP)/rho(T) (order of 10(3)-10(6)), broadly validating the sub-aM detection limits reported in literature, (ii) offers intuitive interpretation for the counter-intuitive rho(T)-independence of detection time in MP-sensors, (iii) shows that statistical fluctuations should reduce with rho(T) for MP sensors, and (iv) offers obvious routes to sensitivity improvement of classical sensors.
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