Journal
HEPATOLOGY RESEARCH
Volume 37, Issue -, Pages S135-S138Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1872-034X.2007.00176.x
Keywords
multistage hepatocarcinogenesis; adenomatous hyperplasia; early HCC; gene expression
Categories
Ask authors/readers for more resources
As is observed in many types of human cancers, hepatocellular carcinoma (HCC) is characterized by an obvious multistage process of tumor progression. Histopathological and molecular biological studies have revealed that HCC associated with chronic liver disease evolves from precancerous lesions called adenomatous hyperplasia (also called dysplastic nodules) and early HCC to a progressed form. Early HCC corresponds to in situ or microinvasive carcinoma, and develops to progressed HCC through the stage of nodule-in-nodule type HCC (progressed HCC within early HCC), which indicates a transition from early to progressed HCC. It is considered that early HCC is a key step in the process of HCC development and progression. However, the molecular mechanisms of early hepatocarcinogenesis are far from clear. Specific mutations of classical oncogenes or tumor suppressor genes have not been identified in early HCC so far. Recent progress in comprehensive analysis of gene expression is shedding some light on this issue.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available