Journal
JOURNAL OF CARDIOVASCULAR MEDICINE
Volume 8, Issue -, Pages S4-S10Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.2459/01.JCM.0000289269.98105.65
Keywords
fish oils; pharmacokinetics; n-3 polyunsaturated fatty acids
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Current evidence suggests that at least part of the cardioprotective benefits of consumption of long-chain n-3 polyunsaturated fatty acids (PUFAs) relates to their incorporation into the phospholipids of cardiac cell membranes. Dietary supplementation with purified extracts of n-3 PUFAs derived from fish oil rapidly alters the composition of fatty acids in blood cell membranes and in other tissues. The present review summarises the time-course and dose-dependent incorporation and washout of n-3 PUFAs in the clinical setting and discusses the implications of these pharmacokinetic data in terms of biological effects.
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