Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 77, Issue -, Pages S49-S57Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2007.01.033
Keywords
GSK3; insulin signaling; glucose homeostasis
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Funding
- NIDDK NIH HHS [DK36836, DK63225] Funding Source: Medline
- Ministry of Education, Science & Technology (MoST), Republic of Korea [E070800] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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GSK3 has been implicated in the development of insulin resistance, primarily based on its role in regulation of glycogen synthesis. However. GSK3 is involved in many other important signaling cascades which may regulate glucose homeostasis and the development of insulin resistance. In addition, GSK3 is composed of two isoforms, GSK3 alpha and beta, which do not completely share their physiological roles, and this raises a possibility that GSK3 alpha and beta may function differently in glucose homeostasis. In this review, we will give an overview to examine potential mechanisms for the roles of GSK3 in the development of insulin resistance. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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