Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 583, Issue 2, Pages 431-436Publisher
WILEY
DOI: 10.1113/jphysiol.2007.136051
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Funding
- NIDA NIH HHS [R01 DA016994, DA16994] Funding Source: Medline
- NIDDK NIH HHS [DK28172, R01 DK028172, R37 DK028172] Funding Source: Medline
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Glucocorticoids act primarily in a feed-forward fashion on brain to activate CNS pathways that implement wanting appropriate to physiological needs. Thus, depending on the available conditions, elevated glucocorticoids may augment the behavioural want to run, fight or feed. Although glucocorticoids stimulate intake of chow, fat and sucrose, insulin appears to sculpt calorie-associated desires toward foods high in fat, acting through hepatic branch afferents of the vagus nerve. Both conditions of reduced food allowance and chronic stress excite glucocorticoid-augmented central neural networks that may lead toward ultimate abdominal obesity.
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