Journal
ANALYST
Volume 134, Issue 10, Pages 2158-2164Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b909581k
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Funding
- National Science Fund for Distinguished Young Scholars [20625516]
- Science Fund for Creative Research Groups [20621502]
- National 973 project of China [2007CB914200]
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A novel boronate affinity monolith, poly(3-acrylamidophenylboronic acid-co-ethylene dimethacrylate) (AAPBA-co-EDMA), was prepared in 530 mu m capillaries by a one-step in situ polymerization procedure using a pre-polymerization mixture consisting of functional monomer 3-acrylamidophenylboronic acid, cross-linker ethylene dimethacrylate, porogenic solvent methanol with added poly(ethylene glycol) 20 000 (PEG 20 000) and initiator azobisisobutyronitrile (AIBN). The preparation of the monolith was optimized by investigating the ratio of functional monomer to cross-linker and the effect of poly(ethylene glycol) molecular weight. The resulting boronate monolith was used as a sorbent for polymer monolith microextraction (PMME). Using nucleosides as the testing analyte, the extraction performance of this boronate monolith towards glycol-containing compounds was examined. Finally, the boronate monolith was applied for selective enrichment of glycopeptides and glycoproteins.
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