4.5 Article

N-methylimidazole as a promising catalyst for the Aza-Michael addition reaction of N-heterocycles

Journal

SYNTHESIS-STUTTGART
Volume -, Issue 17, Pages 2653-2659

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-983816

Keywords

N-methylimidazole; Michael additions; nucleophiles; heterocycles; alpha,beta-unsaturated compounds

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N-Methylimidazole has been shown to be a promising catalyst for aza-Michael reactions. Various N-heterocycles were introduced to alpha,beta-unsaturated carbonyl compounds employing N-methylimidazole (0.05 equiv) in a highly efficient, rapid and high yielding synthesis of N-heterocyclic derivatives.

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