Journal
TETRAHEDRON LETTERS
Volume 48, Issue 36, Pages 6239-6244Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.07.044
Keywords
multicomponent reaction (MCR); isocyanide; aminopyrazine; pyrazine ring synthesis; trimethylchlorosilane (TMSCI)
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New trimethylehlorosilane (TMSCI) promoted multicomponent reaction (MCR) of ethylenediamine(s), diverse carbonyl compounds, and isocyanides is proposed for the synthesis of a variety of highly substituted 3,4,5,6-tetrahydropyrazin-2-amines including corresponding spirocyclic compounds. (c) 2007 Elsevier Ltd. All rights reserved.
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