Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 36, Pages 14233-14236Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0700392104
Keywords
correlation spectroscopy; four wave mixing
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Funding
- NIGMS NIH HHS [GM59230, R01 GM059230] Funding Source: Medline
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We propose to use infrared coherent two-dimensional correlation spectroscopy (2DCS) to characterize the fibril structure of Ab42, the dominant composition of Ab deposit, which is crucial for investigating its toxicity and aggregation mechanism. By optimizing the pulse polarization configurations with a genetic algorithm combined with sensitivity analysis, we obtained signals with well resolved cross-peak features attributed to the couplings within and between different structural motifs. These signals may provide new constraints for refining of the currently available NMR structure. Two-dimensional correlation spectroscopy also can differentiate the turn structure of Ab42 and other Ab derivatives.
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