Journal
FEBS LETTERS
Volume 581, Issue 22, Pages 4132-4138Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.07.075
Keywords
RNA editing; PPR protein; DYW domain; plant evolution
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RNA editing in plant organelles is an enigmatic process leading to conversion of cytidines into uridines. Editing specificity is determined by proteins; both those known so far are pentatricopeptide repeat (PPR) proteins. The enzyme catalysing RNA editing in plants is still totally unknown. We propose that the DYW domain found in many higher plant PPR proteins is the missing catalytic domain. This hypothesis is based on two compelling observations: (i) the DYW domain contains invariant residues that match the active site of cytidine deaminases; (ii) the phylogenetic distribution of the DYW domain is strictly correlated with RNA editing. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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