Journal
FEBS LETTERS
Volume 581, Issue 22, Pages 4172-4178Publisher
WILEY
DOI: 10.1016/j.febslet.2007.07.049
Keywords
articular cartilage; zonal organization; chondrocyte; hydrogel; extracellular matrices; gene expression
Funding
- NIBIB NIH HHS [R01 EB 05517, R01 EB005517, R01 EB005517-04] Funding Source: Medline
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We investigated the biological response of chondrocytes isolated from different zones of articular cartilage and their cellular behaviors in poly (ethylene glycol)-based (PEG) hydrogels containing exogenous type I collagen, hyaluronic acid (HA), or chondroitin sulfate (CS). The cellular morphology was strongly dependent on the extracellular matrix component of hydrogels. Additionally, the exogenous extracellular micro-environment affected matrix production and cartilage specific gene expression of chondrocytes from different zones. CS-based hydrogels showed the strongest response in terms of gene expression and matrix accumulation for both superficial and deep zone chondrocytes, but HA and type I collagen-based hydrogels demonstrated zonal-dependent cellular responses. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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