Journal
ANALYST
Volume 133, Issue 10, Pages 1409-1415Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b802836b
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Funding
- National Basic Research Program of China [2007CB936000]
- National Natural Science Funds for Distinguished Young Scholar [20725518]
- Major Program of National Natural Science Foundation of China [90713019]
- National Natural Science Foundation of China [20575036]
- Important Project of Natural Science Foundation of Shandong Province in China [Z2006B09]
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An NIR (near-infrared)fluorescent probe TCP (tricarbocyanine diphenylphosphine) including a non-conjugated 'pre-tricarbocyanine' was designed and synthesized for visualizing lipid hydroperoxides (ROOH) in living cells. The excitation and emission spectra of tricarbocyanine in the NIR region can effectively avoid background fluorescence interference in biological systems. The probe exhibited a rapid fluorescence response to ROOH and high selectivity for ROOH over other ROS (reactive oxygen species) and some biological compounds, and the limit of detection was 38 pM. In addition, the probe was stable, and less cytotoxic, which indicated that it has potential application in detecting lipid hydroperoxides in living biological systems.
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