4.7 Article

Novel generation of pH indicators for proton magnetic resonance spectroscopic imaging

Journal

JOURNAL OF MEDICINAL CHEMISTRY
Volume 50, Issue 18, Pages 4539-4542

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jm070044j

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We describe the synthesis of 1,omega-di-IH-imidazoles 2 and 3, derived from L-threitol and D-mannitol, respectively, showing suitable magnetic and toxicological properties, as novel extracellular pH indicators for (1)H spectroscopic imaging by magnetic resonance methods.

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