Journal
SCIENCE
Volume 317, Issue 5843, Pages 1400-1402Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1143708
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Funding
- BBSRC [BBS/E/C/00004880] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/C/00004187, BBS/E/C/00004494, BBS/E/C/00004880] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/C/00004880, BBS/E/C/00004187, BBS/E/C/00004494] Funding Source: Medline
- NHGRI NIH HHS [U54 HG003067] Funding Source: Medline
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We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.
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