Journal
JOURNAL OF CLINICAL ONCOLOGY
Volume 25, Issue 26, Pages 4033-4042Publisher
AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.2007.11.3985
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Funding
- NCI NIH HHS [R01 CA115767-03, R21 CA099237, R21 CA099237-02, P01 CA080124-08, R01 CA115767, P01 CA80124, P01 CA080124] Funding Source: Medline
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Although still in very early stages of clinical development, the combination of antiangiogenics with contemporary chemoradiotherapy regimens has emerged as a feasible and promising approach to many cancers. We review the rationale and the current understanding of antiangiogenics and their therapeutic potential in combination with chemoradiotherapy. Finally, we offer a perspective on future research directions aimed at making this complex therapeutic approach successful in the clinic.
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