Journal
ORGANIC LETTERS
Volume 9, Issue 19, Pages 3741-3744Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol7015093
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- NCI NIH HHS [R01-CA83831] Funding Source: Medline
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We report improved syntheses of the Pennsylvania Green and 4-carboxy-Pennsylvania Green fluorophores; the latter compound was prepared from methyl 4-iodo-3-methylbenzoate in a three-pot process (32% overall yield). Chinese hamster ovary cells expressing O-6-alkylguanine-DNA alkyltransferase fusion proteins were treated with Pennsylvania Green and Oregon Green linked to O-6-benzyiguanine (SNAP-Tag substrates). Analysis of living cells by confocal microscopy revealed that Pennsylvania Green derivatives exhibit substantially higher cell permeability than analogous Oregon Green-derived molecular probes.
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