Amplified electrochemical detection of DNA through Au nanoparticles on electrodes and the incorporation into the DNA-crosslinked structure

The amplified electrochemical sensing of DNA is accomplished by the analyte-induced aggregation of nucleic acid-functionalized An nanoparticles, deposition of the aggregates on a thiolated monolayer-functionalized electrode, and the voltammetric analysis of the redox-active methylene blue intercalated in the nucleic acid duplexes associated with the aggregates.