Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 15, Issue 18, Pages 6119-6125Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.06.035
Keywords
cepharadiones A and B; oxoaporphines; suzuki coupling; cytotoxicity
Funding
- NCI NIH HHS [CA50771] Funding Source: Medline
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Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described. (c) 2007 Elsevier Ltd. All rights reserved.
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